Work

Significantly higher rates of KIDINS220 polymorphisms in patients with obesity and end-stage renal disease

Year: 2024

Type: article

Abstract: Background: Kinase D-interacting substrate of 220 kDa ("KIDINS220") is an integral plasma membrane protein essential to signaling throughout the body; abnormalities are linked to a variety of disorders, including obesity, but have never been directly linked to chronic- or end-stage renal disease. Methods: test of independence was utilized to compare genetic mutation rates in this cohort to all individuals tested nationally. Results: < 0.0001) compared to the national positivity rate of all individuals tested for genetic causes of obesity. Conclusions: Mutations within KIDINS220 may play a modulatory role in the progression of chronic kidney disease in patients with obesity, as evidenced by this small retrospective study. The relationship between KIDINS200, kidney disease, and obesity is complex and requires further study, but may represent a potential therapeutic target in the future.

Source: Obesity Pillars

DOI: 10.1016/j.obpill.2024.100155

Authors: Jesse Richards, Madisen Fae Dorand, Maria Paszkowiak, Sana Ahmed, Courtney McCorkle, Pranay Kathuria

Institutions: University of Oklahoma - Tulsa, University of Oklahoma

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000