Inflammation as a driving force of neurodegeneration. Fundamentals of personalized diagnostics and treatment
Year: 2024
Type: article
Abstract: The CNS integrates efferent signals from the somatic and autonomic parts. Also the CNS also receives information from the periphery about inflammation and infection. Cytokines, chemokines and damage-associated soluble mediators of systemic inflammation can also enter the CNS via the blood and/or lymphatic systems. At the same time these substances can penetrate directly through periventricular structures, as well as by increasing the permeability of the blood-brain barrier and disrupt the healthy functioning of neurons and glia, leading to a violation of brain homeostasis. This can lead to the onset of a neurodegenerative disease or worsen its clinical symptoms. In this publication, we present current international scientific data indicating a link between the neurodegenerative process and immune disorders. In addition to identifying immune-mediated pathways of neurodegeneration, new, potentially significant, immunomodulatory targets are presented for the development of possible effective therapy for this group of diseases.
Authors: E. V. Vist, A. V. Boika, M. M. Sialitski
Institution: Belarusian State Medical University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405047019