Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment
Year: 2024
Type: article
Study design: Observational Study
Abstract: Introduction: This study aims to investigate the relationship between olfactory identification (OI) and cognitive impairment by examining OI abilities across various stages of cognitive deterioration. Methods: A total of 264 participants were divided into three groups based on cognitive status: cognitively healthy, subjective cognitive, and mild cognitive impairment. All participants were assessed using the Sniffin’ Sticks Olfactory Identification test and a comprehensive neuropsychological test battery. Results: Our results highlight the main effects of age and cognitive status on OI scores. Regarding cognitive abilities, OI is associated with measures of short-term memory, long-term, working memory, and selective attention. Finally, logistic regression models showed that OI is a significant predictor for discriminating SCD from CH, MCI from CH, and MCI from SCD. Discussion: These findings suggest the addition of olfactory identification measures in neuropsychological assessments could improve the early detection of individuals at risk for cognitive impairment.
Institution: Universidad Complutense de Madrid
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,591
OpenAlex ID: W4405071673
