Year: 2024
Type: article
Abstract: approach in cancer treatment. To produce siRNA, short nucleotide sequences are generated exogenously. siRNA inhibits target gene expression in a sequence-specific manner and initiates RNA interference (RNAi) in cells. SiRNA is a recently popularized nucleic acid-based medication that shows unique promise in the treatment of cancer. Before clinical siRNA delivery devices are created, there are still a lot of challenges to be solved. This review covers the potential targets for siRNA drug design, elucidates the characteristics and advantages of siRNA drugs and provides a summary of the available clinical siRNA therapies for cancer treatment. Therapeutically complex siRNA chemical alterations and delivery systems are described, and bio-responsive materials for siRNA release have been classified. This study will support continued advancements in clinical applications of siRNA by acting as a resource for disseminating information for more accurate and effective targeted delivery systems.
Author: Aisha Alhaddad
Institution: Taibah University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W4405073932