Work

Immunomodulatory Nanofibrous Membrane Based on Collagen/Curdlan Acetate for Accelerated Wound Repair

Year: 2024

Type: article

Abstract: Collagen is a key component in the extracellular matrix (ECM) with potent immunoregulatory and wound-healing functions. However, its limited processability and stability have hindered its application as a wound dressing. To this end, a composite nanofibrous membrane based on Curdlan acetate (CDA) and bovine type I collagen was developed to broaden the utility of collagen in wound repair. The CDA/collagen nanofibrous membrane (CDAColNM5) demonstrated an average fiber diameter of ∼100 nm, a tensile strength of ∼3.4 MPa, and a swelling degree of ∼540%. The composite membrane also supported the adhesion and proliferation of 3T3 fibroblast cells while upregulating the expression of pro-regenerative cytokines such as IL-6, IL-10, and TGF-β in macrophage models. The immunomodulatory and wound-healing activities of CDAColNM5 were also verified in an animal study. Therefore, these findings suggest that CDAColNM5 represents a promising option for wound management.

Source: ACS Applied Polymer Materials

DOI: 10.1021/acsapm.4c02968

Authors: Qiang Ding, Tian Chen, Chaoxi Wu, Shunqing Tang

Institutions: Hunan University of Arts and Science, Jinan University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Education Department of Hunan Province, National Natural Science Foundation of China, Guangzhou Municipal Science and Technology Bureau