On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment
Year: 2024
Type: article
Abstract: ABSTRACT Overcoming line broadening of labile protons and achieving high‐resolution NMR spectra is crucial for the structural and conformational analysis of organic molecules. Recently, Ma et al. (Magn. Reson. Chem. 2024, 62, 198–207) demonstrated the effectiveness of 2,2,2‐trifluoroacetic acid (TFA) in sharpening NMR signals for nitrogen‐containing compounds which exhibit prototropic tautomerization or conformational isomerism using high molar ratio of [acids]/[solute] ~ 5 to 200. In this commentary, we provide an overview of earlier publications and highlight the extensive applications of TFA in enhancing NMR resolution across a variety of organic functional groups, with the use of very small ratios of [acids]/[solute] ~ 10 −3 to 10 −2 . The prospects for the unequivocal structure analysis using labile protons as the starting point will be analyzed.
Source: Magnetic Resonance in Chemistry
DOI: 10.1002/mrc.5499
Institution: University of Ioannina
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W4405086953