Work

[Role of Mitochondria in Ferroptosis and Its Relationship to Tumors].

Year: 2024

Type: article

Abstract: Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis, characterized primarily by the accumulation of intracellular iron and increased levels of lipid peroxidation. Resistance of tumor cells to ferroptosis can promote tumorigenesis and tumor progression. Various compounds can influence tumor development by triggering ferroptosis. Ferroptosis involves complex regulatory mechanisms, with mitochondria serving as both an iron storage and metabolic center, playing a crucial regulatory role in ferroptosis. This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis, progression, and treatment, as well as the regulatory mechanisms of mitochondria in ferroptosis. .

Source: PubMed

DOI: 10.3779/j.issn.1009-3419.2024.102.34

Authors: Zhanrui Zhang, Hongyu Liu, Jun Chen

Institutions: Shihezi University, First Affiliated Hospital of Shihezi University Medical College, Tianjin Medical University General Hospital, Tianjin Medical University

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation of Tianjin City