Work

Antiviral immunity lassoed down by excess RNA

Year: 2024

Type: article

Abstract: Two complementary works by Chan et al. (https://doi.org/10.1084/jem.20231725), and Ru et al. (https://doi.org/10.1084/jem.20240010), identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem. These studies provide molecular insight into virus-associated severe brainstem encephalitis through PKR inactivation.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20241743

Authors: Erika Valeri, Anna Kajaste-Rudnitski

Institutions: Research Institute of Molecular Pathology, The San Raffaele Telethon Institute for Gene Therapy, Vienna Biocenter, University of Pavia

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: European Research Council