Work

Effect of postbiotic Lactiplantibacillus plantarum LRCC5282 on obesity improvement by modulation of the gut microbiome

Year: 2024

Type: article

Abstract: This study aimed to evaluate the ameliorating effects of Lactiplantibacillus plantarum LRCC5282 (5282-P) postbiotic on obesity. Treatment with 5282-P decreased the ratio of Firmicutes / Bacteroidetes , increased the abundance of obesity regulation-associated genera, including Bacteroides , and elevated the production of short-chain fatty acids. These microbiome alterations correlated with reductions in adipose tissue weight, improvements in serum lipid profiles , and alleviation of obesity symptoms, including body weight and BMI . Additionally, the mRNA expression levels of adipogenesis-related genes, including leptin, PPAR/γ, SREBPα1, and CEBP/α, were significantly downregulated. These findings suggest that 5282-P enhances metabolic health and improves obesity by promoting a diverse and balanced gut microbiome , making it a promising therapeutic candidate for obesity treatment.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2024.106622