Work

Eggshell membrane, a resistant protein, possesses prebiotic-like properties in improving gut microbiota composition and gut-liver axes in chronologically aged C57BL/6J male mice

Year: 2024

Type: article

Abstract: Aging-induced gut dysbiosis may contribute to inflammation and obesity, potentially elevating the risk of age-related chronic diseases. In this study, we aimed to investigate the effects of diet supplemented with 8% eggshell membrane (ESM) on gut microbial composition in chronologically aged C57BL/6J male mice (53-week-old) compared to those of young (8-week-old) and age-matched control mice. After a 24-week dietary intervention, the ESM-fed group exhibited an increased abundance of butyrate-producing and valerate-producing bacteria, accompanied by a significant increase in the cecal concentrations of isobutyrate, isovalerate, and valerate. Furthermore, the ESM-supplemented diet led to reduced expression of Srebf1 , Acaca , Elovl6 , and Scd1 , suggesting a potential role for short-chain fatty acids in the suppression of hepatic lipogenesis. Additionally, reduced hepatic triglyceride levels showed an association with the downregulation of Atgl and Cpt1a , two key lipolysis-associated genes. These findings highlight the potential of ESM as a functional food ingredient that can support healthy aging.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2024.106610

Authors: Dwina Juliana Warman, Huijuan Jia, Yukio Hasebe, Hisanori Kato

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $2,500

Funder: Japan Society for the Promotion of Science