Lipoprotein(a) and the risk of type I cardiorenal syndrome in patients with coronary artery disease: A retrospective clinical study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: The present study aimed to investigate the correlation between lipoprotein(a) (Lp-a) and coronary artery disease (CAD) complicated by type I cardiorenal syndrome (CRS). Methods: ). A comparative analysis of baseline characteristics, lipid profiles, ejection fraction (LVEF), left atrial size (LA), end-diastolic interventricular septal thickness (IVSd), left ventricular end-diastolic dimension (LVEDD), and left ventricular end-systolic dimension (LVESD) between the two groups was performed. Multivariable logistic regression analysis was applied to assess the association between serum lipoprotein(a) (Lp-a) levels and the occurrence of CRS. Results: A total of 269 patients were included, comprising 149 males and 120 females with an average age of 76.0 ± 11.4 years. Significant differences were observed between the CRS and SHF groups in terms of age, history of hypertension, diabetes, myocardial infarction, serum triglycerides, Lp-a, and creatinine (all P < 0.05). Spearman's correlation analysis revealed an inverse relationship between Lp-a and e-GFR (r = -0.588, P < 0.05). Multivariable logistic regression analysis indicated that Lp-a (OR = 1.980, 95 % CI: 1.269-2.992, P = 0.027) and age (OR = 1.584, 95 % CI: 0.955-1.913, P = 0.006) were positively associated with the development of CRS. Conclusion: Serum Lp-a levels are positively correlated with the occurrence of CRS, potentially serving as an independent risk factor for CRS.
Source: IJC Heart & Vasculature
Authors: Zhenhua Jiang, Hailiang Ma, Jianqiang Meng, Dewen Zhu, Yuanben Lu
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,930
OpenAlex ID: W4405098943