Synthesis of Caged HMG-CoA Reductase Substrates for the Elucidation of Cellular Pathways
Year: 2024
Type: article
Abstract: The synthesis of photocaged substrates of the biologically important enzyme HMG-CoA reductase is reported. HMG-CoA bearing a p-hydroxyphenacyl (pHP) photocage moiety was synthesized in an overall yield of 14% over seven steps in addition to caged forms of mevalonate and mevaldehyde. The absorption maximum and quantum yield for decaging of the photocaged compounds is pH dependent with a lambda (max) = 330 nm and a quantum yield of 5%, respectively, at pH 9.1 but lambda (max) = 290 nm and a quantum yield of 16% at pH 6.7.
Source: The Journal of Organic Chemistry
Authors: Ryan J. O’Connell, Nicholas J. Dolphin, Guillermo Ferraudi, Mijoon Lee, Cynthia V. Stauffacher, Paul Helquist, Olaf Wiest
Institutions: University of Notre Dame, Purdue University West Lafayette
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: G397631972, G9000316668
OpenAlex ID: W4405105075