Work

Comparative immunohistochemical evaluation between primary and metastatic lesion in a feline osteosarcoma - A case report

Year: 2024

Type: article

Abstract: Feline primary bone tumors are rare. Still, osteosarcoma (OSA) composes almost 80 % of malignant bone tumors in cats, affecting mostly elder feline individuals. Many differences are observed between canine and feline OSA regarding radiographic image and tumoral behavior, especially metastasis development. This case reports a cat diagnosed with digital osteosarcoma who developed pulmonary metastasis and other digital lesions over one year and half later. Simultaneous immunohistochemical analysis from both primary and metastatic tumoral tissues was performed using diagnostic and prognostic biomarkers panel for bone tumors in order to better understand such aggressive behavior in a feline patient. Similarities and differences from both lesions results revealed intrinsic mechanisms promoting osteosarcoma invasion in this cat.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e40959

Authors: Lyvia Cabral Ribeiro Carvalho, Camila Barbosa Amaral, Bárbara Paula dos Santos Batista, Ana Maria Reis Ferreira, Juliana da Silva Leite

Institution: Universidade Federal Fluminense

Language: English

Topic: Veterinary Oncology Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100