PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis
Year: 2024
Type: article
Abstract: M1-like MoMFs. Additionally, scRNA-seq indicated that PPARα agonist regulated the developmental trajectory and homeostasis of hepatic macrophages. Mechanistically, PPARα agonist may influence the expression of immune regulators in heterogeneous macrophages to exert protective effects against cholestasis. In addition, the CCL and MIF signaling pathways may participate in the communication among hepatic immune cells, including macrophages, neutrophils, natural killer cells, and dendritic cells, in response to the PPARα agonist. In conclusions, PPARα agonist alleviated cholestatic liver injury by attenuating the inflammatory response and restoring hepatic macrophage homeostasis. This study might enhance the understanding of the immunoregulatory mechanisms of PPARα agonists, providing promising therapeutic targets for cholestatic liver diseases.
Authors: Qingmiao Shi, Chen Xue, Yifan Zeng, Qingfei Chu, Shuwen Jiang, Yaqi Zhang, Xin Yuan, Danhua Zhu, Lanjuan Li
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,260
Award: G3783743390
OpenAlex ID: W4405105698