Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides
Year: 2024
Type: article
Abstract: By virtue of benzothiaselenazole-1-oxides as versatile building blocks and masked sulfoximines, we present a novel and practical trifluoromethylselenolation/fluoroalkylselenolation strategy via Ag(I)-mediated selenium nitrogen exchange (SeNEx) reaction with readily available nucleophilic fluoroalkylation reagent. This protocol provides a novel bonding mode for constructing the fluoroalkylseleno (SeR f ) moiety. Besides, it also features mild conditions and good compatibility, enabling the rapid incorporation of SeR f into the intriguing sulfoximine pharmacophore . Further divergent conversion of trifluoromethylseleno (SeCF 3 )-containing sulfoximines strengthens the synthetic utility of the developed transformation.
Source: Green Synthesis and Catalysis
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: diamond
Awards: G1788603189, G549179242, G659205430
OpenAlex ID: W4405106374