Work

A Practical Format to Organize Cancer Constellations Using Innate Immune System Biomarkers: Implications for Early Diagnosis and Prognostication

Year: 2024

Type: article

Abstract: Cancer discovery is directed at the identification of a specific cancer type which allows for specific therapeutic interventions. BACKGROUND/OBJECTIVES: Recently, similar immune checkpoint therapeutics have been applied with success across several cancer types, opening the field for other immune disruptive interventions that have practical applications. METHODS: We have discovered an innate immune system (InImS) biomarker that allows for the characterization of allied cancer subtypes and outliers that might aid with diagnosis, treatment, and prognostication. RESULTS: These InImS biomarkers are related to PD-L1 treatment outcomes and can be potentially manipulated by dietary means. CONCLUSIONS: The FERAD (ferritin-fecal p87) and absolute neutrophil/lymphocyte (aNLR) ratios are two such InImS biomarkers and we show herein, that they allow for the discovery of diagnosis and prognostication patterns, as demonstrated by this study.

Source: International Journal of Translational Medicine

DOI: 10.3390/ijtm4040050

Authors: Martin Tobi, Harvinder Talwar, Noreen F. Rossi, Warren Lockette, Benita McVicker

Institutions: John D. Dingell VA Medical Center, Wayne State University, VA Nebraska Western Iowa Health Care System, University of Nebraska Medical Center

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,137