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EMC3 is critical for CFTR function and calcium mobilization in the mouse intestinal epithelium

Year: 2024
Type: article
Abstract: We generated mice in which endoplasmic reticulum membrane protein complex (EMC) subunit 3 was deleted from intestinal epithelium cells and studied the molecular functions of EMC in vivo. Our findings demonstrate the importance of intestinal EMC in the biogenesis of membrane proteins in vivo, including CFTR, and highlight its critical role in maintaining intracellular calcium homeostasis and, consequently, in calcium-dependent functions in the intestine and beyond.
DOI: 10.1152/ajpgi.00066.2024
Authors: Sarah Penrod, Xiaofang Tang, Changsuk Moon, Jeffrey A. Whitsett, Anjaparavanda P. Naren, Yunjie Huang
Language: English
Subfield: Cell Biology
Open Access status: hybrid
Funders: Cystic Fibrosis Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea, G1628476732, G1679780777, G1726461834, Editing Alveolar Progenitor Cells for Correction of Monogenic Disease, G327302100, G385886714, G3865822283, G4475200149, G4567475708, Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM), G6677950526, G8071432138
OpenAlex ID: W4405117155
FWCI: 0.189
Cites: 54
Cited by: 1
Related to: 10