Work

P-95 Sarcopenia: Risk Factor for Mortality in Cirrhotic Patients on Waiting List for Liver Transplantation in a Reference Center, Colombia

Year: 2024

Type: article

Abstract: Conflict of interest No Introduction and Objectives Sarcopenia is an independent predictor of mortality in patients with chronic liver disease pre- and post-transplant. Measurement of muscle strength by dynamometry can serve as a surrogate marker of frailty in patients with chronic liver disease , especially in those in whom it is not possible to assess sarcopenia through imaging. Patients / Materials and Methods To determine the association between sarcopenia, complications of cirrhosis and mortality in cirrhotic patients on the waiting list for liver transplant in a liver transplant reference center in Colombia. Methods : An observational, analytical and retrospective study was carried out with a cohort of patients with cirrhosis on the waiting list for liver transplant between 2020 and 2022, in a liver transplant reference center in Colombia. Results and Discussion We included 310 patients with a diagnosis of cirrhosis who were on the liver transplant waiting list and had dynamometry and anthropometry records to calculate the SARC-F index. A bivariate analysis was carried out which shows that a high score in CHILDA, MELD, ICU stay, complications such as SBP, dynamometry measurement and sarcopenia generate an estimate of significant association, taking into account a p <0.05. Subsequently, a multinomial logistic regression model was carried out, chronic kidney disease and sarcopenia stand out as influential factors in mortality with P <0.05. Conclusions Sarcopenia and chronic kidney disease are factors that have a significant association with higher mortality.

Source: Annals of Hepatology

DOI: 10.1016/j.aohep.2024.101709

Authors: Gustavo Andres Diaz Nassif, Geovanny Hernandez Cely

Institutions: Universidad del Rosario, Fundación Santa Fe de Bogotá

Language: English

Topic: Liver Disease and Transplantation

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500