Work

P-111 Characterization of Patients With Primary Sclerosing Cholangitis, in Two Reference Centers, From 2011 to 2023

Year: 2024

Type: article

Abstract: Conflict of interest No Introduction and Objectives Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease, characterized by inflammation with fibrosis and obliteration of the intrahepatic and extrahepatic bile ducts. The process of chronic cholestasis eventually leads to biliary cirrhosis. It is associated with ulcerative colitis (UC) in most cases. Objectives: To describe clinical, laboratory and imaging characteristics of patients with PSC, in two reference centers for liver diseases, from 2011 to 2023. Patients / Materials and Methods Observational, descriptive, retrospective study. Excel is used for data collection. The variables were expressed in frequency, range, mean and percentage. Results and Discussion 16,347 records were reviewed, of which, 36 (0.22%) had the diagnosis of PSC. Four had incomplete medical records so 32 were included. Fifty nine percent were male, the mean age was 43 years, with a range of 20 to 88. The clinical presentation of 75% of the patients was jaundice. Abdominal pain or pruritus were the second and third most frequent symptoms. Pruritus, as an isolated symptom, occurred in 13%. Thirteen percent of the patients were asymptomatic. The liver function test showed a cholestatic pattern in 94% of the patients. The diagnosis was confirmed by cholangio-resonance in 78%, endoscopic retrograde cholangiopancreatography in 6% and a combination of both in 16%. Fifty percent of the patients had associated Inflammatory Bowel Disease (93.75% were UC). One of the 32 patients (3%) presented PSC associated to Autoimmune Hepatitis. The complications were: progression to liver cirrhosis in 53%, bacterial cholangitis in 13%, bile duct stones in 6%. Sixteen percent underwent Liver Transplantation and 28% did not present any complications. Conclusions The first series of patients with PSC in our country is reported. The characteristics of this pathology, in this series, do not differ significantly from the characteristics published in most other countries.

Source: Annals of Hepatology

DOI: 10.1016/j.aohep.2024.101725