P-47 Degrees of Liver Stiffness and Steatosis as Predictors of Preeclampsia Complications
Year: 2024
Type: article
Study design: Observational Study
Abstract: Conflict of interest No Introduction and Objectives Liver damage in preeclampsia is caused by antiangiogenic factors such as soluble tyrosine kinase , placental growth factor , and soluble endoglin . These induce endothelial injury and fibrin deposits in the hepatic microcirculation , thus modifying the physical characteristics of the liver parenchyma and therefore its stiffness. Objectives: To evaluate the correlation between the degree of liver stiffness and the severity of patients with preeclampsia . Patients / Materials and Methods This study was observational, analytical, cross-sectional, and prospective. It included pregnant women from the 20th week of gestation, dividing them into three groups: those with a normal pregnancy, those with pre-eclampsia, and those with severe features of pre-eclampsia. Transient elastography was conducted on all participants. Pregnant women with chronic systemic arterial hypertension or pre-existing liver diseases were excluded. Descriptive statistics for measures of central tendency were utilized, and a univariate analysis was performed, considering kilopascals as the dependent variable, the three groups as fixed factors, and BMI as a covariate. Results and Discussion 34 patients were included, 9 in the control group, 12 in the preeclampsia group and 13 in the preeclampsia with severity features group. The mean gestational age was 32 ± 5.8 weeks. The mean age was 27.26 ± 7.73 years. The mean BMI was 28.88 ± 4.83. The mean kPa in the control group was 4.35 ± 0.98, in the preeclampsia without severity features group 5.05 ± 0.87, and in the preeclampsia with severity features group 6.67 ± 1.84. The mean control group CAP was 202.82 ± 21.26 db/m2, in the preeclampsia without severity features group was 227.81 ± 47.81 db/m2, and in the preeclampsia with severity features group was 215.28 ± 37.41 db/m2. Univariate contrasts were significant for preeclampsia with severity criteria features versus preeclampsia F (2 of 23) = 7.679, p = 0.011. Preeclampsia with severity features versus control F (2 of 22) = 11.134, p = 0.003 Conclusions Liver stiffness significantly increases in patients with preeclampsia and preeclampsia with severity features measured by transient elastography. This increase is due to intrahepatic fibrin deposition , but not by fibrosis (collagen) itself. Transient elastography could be useful as a predictor of severity in patients with preeclampsia.
Source: Annals of Hepatology
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4405119100