Work

P-119 Post-transplant Overall and Graft Survival After Liver Transplantation for Autoimmune Hepatitis

Year: 2024

Type: article

Abstract: Conflict of interest No Introduction and Objectives Autoimmune hepatitis (AIH) represents the cause in 5-6% of the total amount of liver transplant in Brazilian centers. Factors that impact post-transplant outcomes are not well known. Data from the European registry show an overall survival of 79,4% post AIH liver transplant whereas Latin American numbers are scarce. The aim of this study is to evaluate long-term patient and graft survival after liver transplant due to AIH. Patients / Materials and Methods This is a retrospective and observational study that included 85 patients with AIH who received liver transplant at a reference center in Brazil, from 1996 to 2023. Demographic data was collected, and survival curves were performed using the Kaplan-Meier method. Results and Discussion Most of the cohort was composed of white (52,9%) females (71,8%). The median age at transplant timepoint was 27 years, ranging from 11 to 73 years. After LT 15,5% experienced graft lost, with the need of a second or third liver transplant. During the follow-up 32,9% of the patients died, with a mean survival time of 17.5 years (±1.4). The overall survival in 5 years was approximately 80%. There was no difference in survival between males and females. Conversely, patients who were submitted to more than one liver transplant had a poorer overall survival. (Fig.1). Conclusions Preliminary results show a good overall post-transplant survival for AIH, which is in compass with international reports. The necessity of retransplant conveys a worse prognosis. Other features that might impact overall and graft survival are to be further evaluated in this cohort.

Source: Annals of Hepatology

DOI: 10.1016/j.aohep.2024.101733