Year: 2024
Type: article
Abstract: Exosomes are nanoscale extracellular vesicles secreted by nearly all cell types, playing a crucial role in intercellular communication. These vesicles transport biomolecules, including proteins, lipids, and nucleic acids, particularly microRNAs (miRNAs), which regulate post-transcriptional gene expression. In cancer, exosomes influence critical processes such as cell proliferation, angiogenesis, metastasis, and therapeutic resistance by transferring oncogenic or tumor-suppressor miRNAs to recipient cells. Their stability in biological fluids and their ability to protect molecular cargo make them promising candidates for non-invasive diagnostics and targeted therapeutics. This review explores the mechanisms of exosome biogenesis, their molecular composition, and their roles in cancer progression, alongside emerging clinical applications and challenges.
Institution: Universidad Juárez del Estado de Durango
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405123461