Work

A Rare Case of Chronic Lymphocytic Leukemia Transforming Into Waldenström Macroglobulinemia During Ibrutinib Therapy

Year: 2024

Type: article

Abstract: Chronic lymphocytic leukemia (CLL) can rarely transform into Waldenström macroglobulinemia (WM), posing diagnostic and therapeutic challenges. The diagnosis of WM requires bone marrow infiltration by lymphoplasmacytic cells and the presence of IgM gammopathy. Immunophenotypic markers include FMC7+, CD19+, CD20+, and CD138+. The MYD88 mutation is characteristic. Symptoms arise from tumor infiltration and monoclonal protein production. Here, we present a case of CLL transforming into WM during treatment with ibrutinib. Given the rarity of such a transformation, this case may serve as a valuable reference, and further investigation is needed to understand the pathology underlying this transformation.

Source: Cureus

DOI: 10.7759/cureus.75274

Authors: Kazi Samsuddoha, Sylvester Homsy, Mohan Preet, Kamrun Naher

Institution: SUNY Downstate Health Sciences University

Language: English

Topic: Chronic Lymphocytic Leukemia Research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405130495