Work

Magnetic field-induced synergistic therapy of cancer using magnetoplasmonic nanoplatform

Year: 2024

Type: article

Abstract: Combining photothermal and chemotherapy using single nanoplatform is an emerging direction in cancer nanomedicine. Herein, a magnetic field (MF) induced combination of chemo/photothermal therapy is demonstrated using Fe3O4@mSiO2@Au core@shell@satellites nanoparticles (NPs) loaded with chemotherapeutic drug doxorubicin (DOX), both in vitro and in vivo. While the synthesized NPs does not absorb light at ~800 nm, an application of an external MF to the NPs dispersion causes magnetophoretic movement and aggregation of the NPs. This aggregation results in a significant near infrared (NIR) absorption associated with plasmon resonance coupling between the Au satellites in the NPs aggregates. The NPs aggregates revealed an enhanced photothermal conversion efficiency (~67 % versus ~19% for NPs in absence of MF) and an enhanced NIR photothermal effect was observed. A combination of the MF induced NIR photothermal therapy (PTT) with DOX resulted in an efficient killing of NPs treated cancer cells in vitro and tumor growth restriction in 4T1-tumor-bearing mice in vivo. Histological studies showed striking differences in development and malignancy between tumors treated with NPs, MF and an 808 nm laser, and the control treatments, revealing a synergy of the MF-induced NIR PTT and chemotherapy and suggesting a promising tumor treatment strategy.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2024.101393