Work

Study of αvß3 integrin gene expression in the endometrium of women with unexplained recurrent Spontaneous abortion

Year: 2024

Type: article

Abstract: Background: In 50% of cases, the pathogenesis of unexplained recurrent Spontaneous abortion (URSA) is still unclear. ` We assess the αvbeta3 integrin gene expression in fertile and RSA-afflicted women. Methods: Endometrial tissues (biopsies) (30 samples) divided into 15 RSA cases and controls (15) healthy through menstrual cycle in the mid-luteal period. The period of data collection was March 2022–December 2023. The αvß3 gene expression was examined and in compression to fertile women using (qRT-PCR). Results: The relative gene expression of αvß3 integrin was significantly decreased (p-value < 0.05) in RSA women in compression to control subjects. The reduction of αvß3 integrin might have an essential role in the pathogenesis of RSA. Conclusion: Comparing women with unexplained RSA to controls, the expression of integrin was considerably lower. Our results highlight the necessity of additional molecular examination of the endometrial tissue in afflicted women.

Source: Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research

DOI: 10.21608/jbaar.2024.395692

Authors: Zahraa Ch. Hameed, Rusul Ali AL-Masaoodi, Maryam Hadi Jabbar, Zainab Abdul Kareem Abbas, Zahra H. AL-Wazni

Institution: University of Kerbala

Language: English

Topic: Reproductive System and Pregnancy

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $120