Work

Real-world Effectiveness of Tms in Adolescents and Young Adults With Major Depressive Disorder

Year: 2024

Type: article

Abstract: secondary pre-and post-treatment measures of anxiety (GAD-7), somatization (SSD-12), sleep quality (PSQI), and coping ability (coping subscale of 5FWEL).Anatomical MRI was used to inform administration of nTMS over the left dorsolateral prefrontal cortex (120% RMT, 50Hz iTBS, 600 pulses over 3 min).All reported t-tests were two-tailed.Results: 15 participants were included in this preliminary sample.Average depression scores were 15.1 at baseline and 6.5 after 30 sessions (t(14)=7.6,p<.001),however, depression scores also decreased after first week (mean=8.7;t(14)=4.8,p<.001).Remission rates were 60%, response rates were 73%, and nonresponse rates were 27%.Anxiety scores decreased from moderate (mean=12.7)to mild (5.7) (t(14)=5.6,p<.001).Somatization scores decreased from at-risk (mean=25.8)to below risk threshold (12.9).Ability to cope increased from a mean of 56 to 68 or approximately 15 percentiles based on norms tables (t(14)=-5.3,p<.001).Sleep quality differences approached threshold (mean pre=12.1 vs post=9.6;t(14)=2.98,p=.01).Notably, post-treatment depression scores correlated with post-treatment anxiety, somatization, and coping (allp<.01),whereas pre-treatment depression scores did not (allp>.05).Conclusions: This preliminary study suggests neuronavigated TMS resulted in significant depression symptom improvement after one week of treatment and decreases in self-reports of physical symptom burden and anxiety, and increased ability to cope following 30 sessions of treatment.

Source: Transcranial magnetic stimulation .

DOI: 10.1016/j.transm.2024.100028

Authors: Paul E. Croarkin, Scott T. Aaronson, Linda L. Carpenter, Todd M. Hutton, Kenneth Pages, Harold A. Sackeim