Predictive Factors for Major Bleeding in Patients Undergoing Percutaneous Nephrolithotomy: A Clinical Prediction Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate major bleeding risk factors in percutaneous nephrolithotomy (PCNL) for upper urinary tract calculi and validate a prediction model. STUDY DESIGN: Analytical study. Place and Duration of the Study: The First Affiliated Hospital of Wannan Medical College, Wuhu, China, from January 2019 to August 2023. METHODOLOGY: Major bleeding was defined as a decrease in haemoglobin of ≥20 g/L compared to preoperative levels. A retrospective analysis of 468 PCNL patients identified risk factors for major bleeding using univariate, LASSO, and logistic regression analyses. Nomogram models were developed using R software, with ROC and calibration plots assessing the model's accuracy. The bootstrap method provided internal validation, and DCA evaluated clinical utility. RESULTS: Independent risk factors included diabetes (OR = 4.17), staghorn calculi (OR = 3.41), operative duration (OR = 1.01), and staged surgery (OR = 2.75). The model showed high discriminative ability (C-statistic: 0.783) and alignment with observed outcomes. Internal validation confirmed robustness (C-statistic: 0.728). CONCLUSION: The predictive model for major bleeding during and after PCNL, focusing on diabetes, staghorn calculi, operative duration, and staged surgery, is highly accurate, aiding in the PCNL risk assessment. KEY WORDS: Upper urinary tract calculi, Percutaneous nephrolithotomy, Major bleeding, Risk factors, Prediction model.
Authors: Teng Qiu, Xiao-Tao Hu
Institution: First Affiliated Hospital of Wannan Medical College
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405202250