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A Feasibility Study on the Use of UV ‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates

Year: 2024

Type: article

Abstract: ABSTRACT Microneedle (MN) has significant potential for transdermal glucose monitoring. However, challenges remain in selecting suitable materials for long‐acting monitoring MN. In this study, precise solid UV‐curable resin MN patches were fabricated using a synergistic combination of the micromolding method and the UV‐curing procedure, as an alternative to the previous 3D printing. The properties of the UV‐cured resin MN patches prepared using this method were evaluated and characterized, focusing on their potential for long‐acting monitoring. The results demonstrated that the UV‐curable resin MN patches exhibited superior shape stability, very low cytotoxicity, minimal skin irritation, and a fracture force of approximately 2.289 N/needle. Following immersion in 37°C PBS for different days, the shape and mass changed negligibly, and the fracture force still reached half of the original values after 21 days. UV‐curable resin is a highly promising substrate for MN, and the study provides a new material selection strategy for long‐acting monitoring of MN development.

Source: Polymers for Advanced Technologies

DOI: 10.1002/pat.70007

Authors: Baoling Jia, Tiandong Xia, Xiaohui Wang, Yangtao Xu, Bei Li

Institutions: Lanzhou University of Technology, Gansu Provincial Hospital, Gansu Provincial Hospital of TCM

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405207659

FWCI:

Cites: 60

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Related to: 10