Synthesis, characterization, biological activities, and computational studies of pyrazolyl–thiazole derivatives of thiophene
Year: 2024
Type: article
Abstract: ), demonstrating significant inhibition zones and low minimum inhibitory concentrations (MIC). In addition, the compounds exhibited notable antioxidant activities in DPPH and hydroxyl radical scavenging assays. Computational studies, including density functional theory (DFT) calculations and molecular docking simulations, were performed to understand the electronic properties and binding interactions of the synthesized compounds with biological targets. The molecular docking results supported the experimental findings, highlighting the potential of these pyrazolyl-thiazole derivatives as multifunctional therapeutic agents with both antimicrobial and antioxidant properties.
Source: RSC Advances
DOI: 10.1039/d4ra06228k
Authors: Seema K. Bhagwat, Tushar Janardan Pawar, Sayali A. Kulkarni, Amar A. Patil, Rahul Ashokrao More, J. Oscar C. Jimenez-Halla, Juan Andres Alvarado-Salazar, Jose Luis Olivares-Romero, Ghazala Muteeb, Enrique Delgado-Alvarado, Sachin V. Patil
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Awards: G1405527774, G5282492848
OpenAlex ID: W4405208888