Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults
Year: 2024
Type: article
Abstract: In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Therefore, cortical excitability is a candidate biomarker for early AD detection. Moreover, lowering neuronal excitability could potentially complement strategies to reduce Aβ and tau buildup. There is, however, a lack of understanding of the relationship between cortical excitability and p-tau increase in vivo . Therefore, in a sample of 658 healthy middle-aged (between the ages of 40 and 65) participants of the Barcelona Brain Health Initiative cohort study, we examined the relation of blood-based tau, phosphorylated at amino acid 181 (p-tau181), reflecting neuronal p-tau secretion; neurofilament light chain (NfL), as a passively released control for p-tau181; and electroencephalography (EEG) markers of cortical excitability. A subsample of 47 participants also completed a controlled brain perturbation approach via transcranial magnetic stimulation (TMS) with concurrent EEG. Results show that both spontaneous (i.e., resting-state) and perturbation-based TMS-EEG markers, are associated with blood p-tau181, particularly in older individuals. The perturbation-based marker was a significantly more sensitive predictor of p-tau181 concentration than the spontaneous resting state EEG-based marker. The relationships observed are not present for the NfL control. These results show that relationships between p-tau181 and cortical excitability are present in healthy middle-aged subjects and that p-tau181 increases may reflect activity-dependent secretion.
Source: Heliyon
Authors: Ruben Perellón-Alfonso, Kilian Abellaneda-Pérez, Indre Pileckyte, María Cabello-Toscano, Lídia Mulet-Pons, Lídia Vaqué-Alcázar, Gabriele Cattaneo, María Redondo-Camós, Goretti España-Irla, Selma Delgado-Gallen, Javier Solana Sánchez, Henrik Zetterberg, Jose M. Tormos, Nicolai Franzmeier, Alvaro Pascual-Leone, David Bartrés-Faz
Institutions: Universitat Autònoma de Barcelona, Institut Guttmann, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Pompeu Fabra, Hospital de Sant Pau, Northeastern University, University of Wisconsin–Madison, Sahlgrenska University Hospital, UK Dementia Research Institute, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London, University of Gothenburg, Valencia Catholic University Saint Vincent Martyr, Munich Cluster for Systems Neurology, Institut für Schlaganfall- und Demenzforschung, Ludwig-Maximilians-Universität München, Harvard University, Hebrew SeniorLife
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,100
Funders: Alzheimer's Association, Alzheimer's Drug Discovery Foundation, BrightFocus Foundation, Familjen Erling-Perssons Stiftelse, Cure Alzheimer's Fund, “la Caixa” Foundation, Stiftelsen för Gamla Tjänarinnor, EU Joint Programme – Neurodegenerative Disease Research, National Institute for Health and Care Research, University College London, European Commission, Hjärnfonden, Vetenskapsrådet, Ministerio de Ciencia e Innovación, UK Dementia Research Institute, Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona, Olav Thon Stiftelsen, National Institutes of Health, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Horizon 2020, National Institute on Aging, H2020 Marie Skłodowska-Curie Actions
Awards: G1088883541, G1255325603, G150733400, G1588116593, G1771944843, G1802301745, G1832134291, G1833008592, G201353144, Personalized brain activity modulation to improve balance and cognition in elderly fallers, G2290189609, G237833635, G2543812357, Innovative doctoral programme for talented early-stage researchers in Spanish host organisations excellent in the areas of Science, Technology, Engineering and Mathematics (STEM)., G2772962269, G292763017, Fluid biomarkers for neurodegenerative dementias, G3914690605, G4260843567, G432431387, G434337789, G4377393254, G4944594896, G5040492720, G506008078, G5132640529, G516766298, Fluid biomarkers for neurodegenerative dementias, G6004110409, CASCADE: CAuSe or Consequence in Alzheimer DiseasE?, G6158734006, Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis, System biology approach to decode molecular mechanism of glucose metabolism in AD and dementia, Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis, Innovative doctoral programme for talented early-stage researchers in Spanish host organisations excellent in the areas of Science, Technology, Engineering and Mathematics (STEM)., G6745400708, G691317373, G7685134749, G7731791180, G9000132817
OpenAlex ID: W4405212096