Work

The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients

Year: 2024

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Introduction This study aims to evaluate the effects of group computer magnanimous therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer. Methods In this multicenter, randomized controlled trial, 47 participants diagnosed with advanced stage (III or IV) lung cancer were randomly assigned to either the GCMT group (GCMTG, n = 31) or the control group (CTRLG, n = 16). The GCMTG received routine oncotherapy and care along with eight sessions of GCMT over 2 weeks, while the CTRLG received only oncotherapy and routine care. Psychological and brain metabolic changes were assessed using the Enterprising and Magnanimous Questionnaire (EMQ) and proton magnetic resonance spectroscopy (1H-MRS). Results After 2 weeks, the GCMTG showed significant improvements in the EMQ “total score” and “enterprising” dimensions compared to baseline (p < 0.05), while the CTRLG showed no significant changes. Significant increases in NAA/Cr levels were observed in the right amygdala, and significant decreases in mI/Cr levels were observed in the right cingulate gyrus in the GCMTG. Pearson correlation analysis indicated that changes in Cho/Cr levels in the left amygdala and Glx/Cr levels in the left hippocampus were significantly correlated with improvements in the enterprising dimension. Conclusions GCMT significantly enhanced enterprising attitudes and induced beneficial changes in brain metabolites among patients with advanced lung cancer. Further research with larger sample sizes is warranted to confirm these results and explore the long-term effects of GCMT. Clinical trial registration https://www.chictr.org.cn/showproj.html?proj=129557 , identifier ChiCTR2100053015.

Source: Frontiers in Psychiatry

DOI: 10.3389/fpsyt.2024.1397375

Authors: Qianyu Liu, Qihui Ma, Qingfeng Sun, Xuewei Huang

Institutions: Huizhou Central People's Hospital, Guangdong Pharmaceutical University, First Affiliated Hospital of Guangdong Pharmaceutical University

Language: English

Topic: Cancer survivorship and care

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295