Graphene Oxide Decorated SiO2/Fe3O4 as a Recyclable Catalyst for the Green Synthesis of Novel Thiazinoazepines via Multicomponent Reaction of Isatoic Anhydrides: Cytotoxic Activity and Theoretical Study
Year: 2024
Type: article
Abstract: ABSTRACT This work investigated the use of a complex technique including isatoic anhydrides, α‐haloketones, electron‐deficient acetylenic compounds, ammonium acetate, and isothiocyanates in a water‐based solution at normal room temperature in the presence of SiO2/Fe3O4@Graphene Oxide. The goal was to generate novel thiazinoazepine molecules with significant yields. The thiazinoazepines that have been synthesized contain NH functional groups with acidic protons and demonstrate notable antioxidant activity. The (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide), MTT assay was utilized to evaluate the cytotoxicity of all the synthesized compounds in vitro against cancer cell lines (MCF‐7 and A549) as well as normal cell lines). Cytotoxicity refers to the ability of a compound to kill cells. The derivative 6e was shown to be the most potent cytotoxic agent, similar to doxorubicin in its lack of selectivity. Alternatively, compound 6b might be considered as a compound that is equally effective but more selective than doxorubicin. Quantum chemical approaches utilizing density functional theory have been utilized to enhance comprehension of reaction mechanisms. The used technology for synthesizing thiazinoazepines provides several advantages, including rapid reaction kinetics, outstanding product yield, and straightforward product isolation.
Source: Applied Organometallic Chemistry
DOI: 10.1002/aoc.7898
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Islamic Azad University
OpenAlex ID: W4405219971