Work

Lipid droplet specific BODIPY based rotors with viscosity sensitivity to distinguish normal and cancer cells: impact of molecular conformation

Year: 2024

Type: article

Abstract: -biphenyl rings leading to non-radiative deactivation of the excited state, resulting in weak emission. Additionally, this structural feature makes them highly responsive to changes in viscosity. As the glycerol concentration increased from 0% to 99%, the fluorescence intensity of compounds 5a, 5b, and 5c increased dramatically by 17-fold, 78-fold, and 43-fold, respectively. In contrast, compounds 6a-c, with restricted phenyl ring rotation due to tetra-methyls on the indacene unit, showed only a modest 2-3-fold increment in fluorescence intensity under similar conditions. These fluorophores possess several key advantages, including high selectivity for LDs, good photostability, sensitivity to viscosity, and responsiveness to polarity and pH. Moreover, they effectively differentiate between normal and cancer cells, making them valuable tools for cancer diagnosis and potential therapeutic applications.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d4tb02405b

Authors: Charutha Kalarikkal, Anjali, Sarbani Bhattacharjee, Koyeli Mapa, Chinna Ayya Swamy P

Institution: National Institute of Technology Calicut

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Department of Science and Technology, Ministry of Science and Technology, India, National Institute of Technology Calicut, Science and Engineering Research Board