An International Consensus Practical Guide on Left Atrial Appendage Closure for the Non-implanting Physician: Executive Summary
Year: 2024
Type: article
Abstract: Many patients with atrial fibrillation (AF) who are in need of stroke prevention are not treated with oral anticoagulation or discontinue treatment shortly after its initiation. Despite the availability of direct oral anticoagulants (DOACs), such undertreatment has improved somewhat but is still evident. This is due to continued risks of bleeding events or ischemic strokes while on DOAC, poor treatment compliance, or aversion to anticoagulant therapy. Because of significant improvements in procedural safety over the years left atrial appendage closure (LAAC), using a catheter-based, device implantation approach, is increasingly favored for the prevention of thromboembolic events in AF patients who cannot have long-term oral anticoagulation. This article is an executive summary of a practical guide recently published by an international expert consensus group, which introduces the LAAC devices and briefly explains the implantation technique. The indications and device follow-up are more comprehensively described. This practical guide, aligned with published guideline/guidance, is aimed at those non-implanting physicians who may need to refer patients for consideration of LAAC.
Source: Thrombosis and Haemostasis
DOI: 10.1055/a-2469-4896
Authors: Tatjana Potpara, Marek Grygier, Karl Georg Haeusler, Jens Erik Nielsen-Kudsk, Sergio Berti, Simonetta Genovesi, Eloi Marijon, Serge Boveda, Apostolos Tzikas, Giuseppe Boriani, Lucas V. A. Boersma, Claudio Tondo, Tom De Potter, Gregory Y. H. Lip, Renate B. Schnabel, Rupert Bauersachs, Marco Senzolo, Carlo Basile, Stefano Bianchi, Pavel Osmancik, Boris Schmidt, Ulf Landmesser, Wolfram Doehner, Gerhard Hindricks, Jan Kovac, A. John Camm
Institutions: University of Belgrade, Univerzitetski Klinički Centar Srbije, Poznan University of Medical Sciences, Universitätsklinikum Würzburg, Aarhus University Hospital, Regione Toscana, IRCCS Istituto Auxologico Italiano, University of Milano-Bicocca, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Vrije Universiteit Brussel, Clinique Pasteur, Aristotle University of Thessaloniki, Interbalkan Medical Center, Ippokrateio General Hospital of Thessaloniki, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, St. Antonius Ziekenhuis, Amsterdam University Medical Centers, University of Milan, Centro Cardiologico Monzino, Onze Lieve Vrouwziekenhuis Hospital, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool John Moores University, Aalborg University, German Centre for Cardiovascular Research, Cardiovascular Center Bethanien, University of Padua, Azienda Ospedale - Università Padova, Ospedale Generale Regionale Francesco Miulli, Azienda USL Toscana Nord Ovest, Charles University, University Hospital Kralovske Vinohrady, Agaplesion Markus Hospital, Deutsches Herzzentrum der Charité, Stiftung Charité, Charité - Universitätsmedizin Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, University of Leicester, Glenfield Hospital, St George's, University of London
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Bristol-Myers Squibb, Pfizer, AstraZeneca, Sanofi, Alexion Pharmaceuticals, Edwards Lifesciences, Boston Scientific Corporation, Deutsches Zentrum für Herz-Kreislaufforschung, Amarin Corporation, National Institute for Health and Care Research, European Commission, Bayer HealthCare, Bundesministerium für Bildung und Forschung, Daiichi-Sankyo, Deutsche Herzstiftung, Vifor Pharma, Novo Nordisk Fonden, Sun Pharma, MicroPort, Biosense Webster, Daiichi Sankyo Europe
Awards: Juniorverbünde in der Systemmedizin: Molekulare Charakterisierung von Kandidatengenen und Signalwegen für das Vorhofflimmern sowie Untersuchungen zur Genetischen Epidemiologie (symAtrial), Universitätsklinkum Hamburg-Epppendorf, G1343760766, ATRIAL FIBRILLATION INTEGRATED APPROACH IN FRAIL, MULTIMORBID, AND POLYMEDICATED OLDER PEOPLE, DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY, G2683322055, G3788823993, G434337789, G5539059467, G6015547599, G7581005959, ERACoSysMed3 - Verbundprojekt: PARIS - Personalisierte Vorhofflimmerrisikobestimmung für ischämischen Schlaganfall und Krankheitsverlauf - Projektion hin zu einem vereinheitlichten Machine Learning basierten klinischen Index, G8707897456, G8801197882
OpenAlex ID: W4405220718