Performance of serum IL-18 levels for the follow-up of patients with familial Mediterranean fever
Year: 2024
Type: article
Abstract: Familial Mediterranean fever (FMF) is associated with MEFV mutations, leading to excessive activation of the pyrin inflammasome, which is responsible for the production of proinflammatory IL-1β and IL-18. Continuous and/or repeated inflammation can lead to the life-threatening complication of inflammatory (AA) amyloidosis.1 Disease inactivity is defined as the absence of clinical symptoms and normal values of inflammatory biomarkers. There are several limitations to assessing disease activity. First, flare count may be difficult to assess in some situations (young children and nonspecific symptoms).
Authors: Inès Elhani, Laure Calas, Farah Bejar, Laurence Pieroni, Isabelle Kone-Paut, Linda Rossi-Semerano, Isabelle Melki, Brigitte Bader-Meunier, Bénédicte Neven, Pierre Quartier, Guilaine Boursier, Irina Giurgea, Laurence Cuisset, Gilles Grateau, Véronique Hentgen, Philippe Mertz, Marion Delplanque, Léa Savey, Sophie Georgin-Lavialle
Institutions: Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Tenon, Inserm, Université Pierre-et-Marie-Curie, Bicêtre Hospital, ERN RITA, Hôpital Armand-Trousseau, Hôpital Robert-Debré, Hôpital Necker-Enfants Malades, Université de Montpellier, Centre Hospitalier Universitaire de Montpellier, Centre de Référence des Maladies Autoinflammatoires et des Amyloses, Hôpital Cochin, Centre Hospitalier de Versailles
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W4405220912