Work

Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy

Year: 2024

Type: article

Abstract: We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.

Source: Chemical Communications

DOI: 10.1039/d4cc06309k

Authors: Mayesha B. Mustafa, Jinchao Lou, Miranda A. Phillips, Robert F. Turner, Joshua A. Baccile, Michael D. Best

Institution: University of Tennessee at Knoxville

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences