Work

Dexmedetomidine

Year: 2024

Type: article

Abstract: Recent research highlights the potential of dexmedetomidine, an α2-adrenoreceptor agonist, as a preventive treatment for postpartum depression (PPD). Originally studied in anesthetic settings, dexmedetomidine has shown antidepressant effects, reducing agitation and depressive symptoms. It is sedative, anxiolytic, and analgesic, targeting α2-adrenoreceptors implicated in depression. Studies link increased α2-adrenoreceptor activity and reduced brain-derived neurotrophic factor (BDNF) levels to PPD. Dexmedetomidine appears to modulate these pathways, promoting neuroplasticity and mood regulation.

Source: Archives of Psychiatry Research

DOI: 10.20471/sept.2024.60.03.09

Authors: Vjekoslav Peitl, Darko Vlahović

Institutions: University Hospital Centre Zagreb, Catholic University of Croatia, Sisters of Charity Hospital

Language: English

Topic: Maternal Mental Health During Pregnancy and Postpartum

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405227447

FWCI:

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Related to: 10