Work

Iodine/TBHP‐Promoted Cross Coupling of N ‐Hydroxy Aryl Sulfonamides and Disulfides to Synthesize Unsymmetrical Thiosulfonates

Year: 2024

Type: article

Abstract: An efficient and novel method has been developed for the synthesis of structurally diverse unsymmetrical thiosulfonates via the oxidative coupling reactions of N ‐hydroxy aryl sulfonamides and disulfides. The iodine and TBHP system enables the transformations to afford a variety of thiosulfonates with good to high yields. Furthermore, the large‐scale synthesis and practical application to access sulfonamide have been investigated. Notably, the present protocol offers easily accessible materials, a wide range of substrates, radical pathways, and metal‐free conditions.

Source: ChemistrySelect

DOI: 10.1002/slct.202403361

Authors: Jayshree Solanke, Rana Chatterjee, Savita Gat, Rambabu Dandela

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board

Awards: G1519003904, G1745564834, G2467136082, G3131625124

OpenAlex ID: W4405229456

FWCI: 0.282

Cites: 72

Cited by: 2

Related to: 10