P43 Correlation of SF-36v2 score with disease burden and patient background in Japanese patients with psoriasis vulgaris
Year: 2024
Type: conference-abstract
Abstract: Psoriasis vulgaris is a chronic inflammatory skin disease that accounts for 0.3–0.4% of the Japanese population and is known to reduce the QoL of affected individuals. However, there are few evaluations of Japanese patients with psoriasis in general health-related quality of life indices such as short form (SF)-36v2. The Western Japan Psoriasis Registry is a prospective cohort conducted by the Western Japan Inflammatory Skin Disease Research Group and currently enrols around 2600 patients. QoL of psoriasis vulgaris patients enrolled in this registry were assessed using a questionnaire including SF36v2. Objective severity of the skin symptom was evaluated by board-certified dermatologists. The study was authorized by the internal review board of each facility and was conducted with the patient’s written consent. A total of 1065 PsV patients (765 males and 300 females) were enrolled. The mean age was 60.3 years; the mean physical component summary (PCS) of SF-36v2 in PsV patients was 47.9, lower than the national average. The scores were significantly lower in items physical functioning and general health. When stratified with demographics, women and those aged over 60 years had lower scores in almost all items. In contrast, habitual drinkers had higher scores on all items. In terms of comorbidities, patients with hypertension and diabetes had lower PCS than those who do not have such comorbidities, while having hyperlipidaemia or hyperuricaemia did not make any difference in scores. Regarding Physical Functioning, scores were higher overall in patients with a current lesion area of <3% and patients with a PGA score of 2 or less. For patients who have lesions on the head/neck and extremities, the scores were lower overall than those who do not have lesions in such areas. In correlation with other patient-reported outcomes, SF-36v2 scores were lower in the group with DLQI >10 than in those with DLQI ≦10. Similar results were found for the patient’s global assessment of severity and Itch NRS. In conclusion, women, older age, non-drinking, concomitant diabetes, objective severity, lesions on the head and neck, extremities, and itching were found to be factors that reduced quality of life in patients with PsV. This study was conducted by the members of the nonprofit organization Western Japan Inflammatory Skin Disease Research Group, and this work is partially supported by Boehringer Ingelheim.
Source: British Journal of Dermatology
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4405230163