Work

Exploring the Crystal Landscape of Mandelamide and Chiral Resolution via Cocrystallization

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The crystal structures of (±)-mandelamide, S -mandelamide, and enantioenriched mandelamide (94 S: 6 R ) were determined. Diastereomeric cocrystal pairs of S -mandelamide with both enantiomers of mandelic acid and proline were synthesized. The diastereomeric cocrystal pairs of S -mandelamide with S / R -mandelic acid form 1:1 cocrystals in each case, while the diastereomeric cocrystal pairs of S -mandelamide with proline have different stoichiometries. Preliminary investigation of this diastereomeric cocrystal system for chiral resolution shows promise.

Source: Crystal Growth & Design

DOI: 10.1021/acs.cgd.3c01513

Authors: Shan Huang, Deirbhile Fitzgerald, Samuel A. Koledoye, Stuart G. Collins, Anita R. Maguire, Simon E. Lawrence

Institutions: University College Cork, Synthesis and Solid State Pharmaceutical Centre

Language: English

Topic: Crystallography and molecular interactions

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Science Foundation Ireland, Irish Research Council