Work

Continuous Flow Synthesis of α‐Chloroketones from Esters

Year: 2024

Type: article

Abstract: Herein, we report a novel and practical strategy to access α‐chloroketones from esters bearing diverse (hetero)aromatic, aliphatic, alkynyl and alkenyl substituents with transient chloromethyllithium under continuous flow conditions. This highly chemoselective method enables a fast (on a time scale of <5 s), efficient and straightforward access to a broad substrate scope (up to 99% yield) with a remarkable throughput of ∼10.6 g/h.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401438

Authors: Léna Brassart, Maxime Manneveau, Thomas Poisson, Julien Legros, Philippe Huez, Massimiliano Forcato, Philippe Jubault, Laëtitia Chausset‐Boissarie

Institutions: Centre National de la Recherche Scientifique, Laboratoire COBRA, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funders: Indian National Science Academy, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Université de Rouen, Institut Carnot Santé Animale, Région Normandie

Awards: XLChem, Synthesizing our future, G2900821844, G3902062375, G4656594441, G5976147578, Synthèse Organique : des molécules au vivant

OpenAlex ID: W4405231489

FWCI: 0.639

Cites: 39

Cited by: 6

Related to: 10