Nomogram for overall survival in ampullary adenocarcinoma using the surveillance, epidemiology, and end results database and external validation
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract. Currently, only a few cases have been reported, resulting in limited information on survival. AIM: To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma. METHODS: Data were sourced from the surveillance, epidemiology, and end results stat database. The patients in the database were randomized in a 7:3 ratio into training and validation groups. Using Cox regression univariate and multivariate analyses in the training group, we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram. The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University. RESULTS: For overall and cancer-specific survival, 12 (sex, age, race, lymph node ratio, tumor size, chemotherapy, surgical modality, T stage, tumor differentiation, brain metastasis, lung metastasis, and extension) and 6 (age; surveillance, epidemiology, and end results stage; lymph node ratio; chemotherapy; surgical modality; and tumor differentiation) independent risk factors, respectively, were incorporated into the nomogram. The area under the curve values at 1, 3, and 5 years, respectively, were 0.807, 0.842, and 0.826 for overall survival and 0.816, 0.835, and 0.841 for cancer-specific survival. The internal and external validation cohorts indicated good consistency of the nomogram. CONCLUSION: The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
Authors: Jia Yang, Zi-Yi Wang, Jing Chen, Yao Zhang, Lei Chen
Institution: Army Medical University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405231545