Work

Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2‐Isoxazolines via a Formal C(sp3)−H Functionalization

Year: 2024

Type: article

Abstract: The discovery of a dehydrogenative photoredox catalyzed formal C(sp3)−H intramolecular cyclization of indolyl‐oximes to generate indolyl Δ2‐isoxazolines is reported. In contrast to the current state‐of‐the‐art, the reaction avoids the use of super stoichiometric chemical oxidants and high reaction temperatures and is proposed to operate via two sequential single electron oxidation events.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401369

Authors: Jonathan Da Luz, Farhaan Dobah, James A. Rossi‐Ashton, Richard J. Payne, William P. Unsworth, Wade F. Petersen

Institutions: University of Cape Town, University of Manchester, University of York, The University of Sydney

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: Royal Society of Chemistry, National Research Foundation