Work

A rare case of complicated typhoid fever presenting with secondary Hemophagocytic Lymphohistiocytosis

Year: 2024

Type: article

Abstract: Enteric fever is one of the important causes of tropical fever with a prevalence of 11–21 million cases worldwide annually. It encompasses both typhoid and paratyphoid fever. Salmonella enterica Typhi is the causative organism for typhoid fever, manifesting as an uncomplicated febrile illness to life-threatening sepsis with multiorgan dysfunction. It is complicated by neuropsychiatric manifestation (2%–40%), gastrointestinal bleeding (10%), and intestinal perforation (1%–3%). Hemophagocytic Lymphohistiocytosis (HLH) is a rare complication of typhoid fever. Herein we report the case of a 24-year-old male from North-Eastern India, presenting with spikes of fever, altered behavior, a generalized rash, haematochezia, and hemophagocytes on bone marrow examination due to hemophagocytic lymphohistiocytosis secondary to complicated typhoid fever.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omae151

Authors: Mir Wasim Ali, Soumadip Rakshit, Atreyee Sarkar, Md Karimulla Mondal, Anup Kumar Datta, Uttara Chatterjee

Institution: Institute of Post Graduate Medical Education and Research

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,180