Work

Iterative One-Carbon Homologation of Unmodified Carboxylic Acids

Year: 2024

Type: article

Abstract: The one-carbon homologation of carboxylic acids is a valuable route to construct families of homologues, which play fundamental roles in chemistry and biology. However, known procedures are based on multistep sequences, use harsh conditions or are limited in scope. Thus, almost a century after the discovery of the original Arndt-Eistert homologation sequence, a general method to directly convert carboxylic acids into their corresponding homologues remains elusive. Exploiting the photoredox reactivity of nitroethylene, we disclose a practical visible-light-induced homologation of unmodified carboxylic acids. Iterations of the procedure reveal an exceptionally tunable strategy for the construction of inert carbon spacers, opening new opportunities in synthesis.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c13630

Authors: Emilie Wheatley, Heorhii Melnychenko, Mattia Silvi

Institution: University of Nottingham

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500