Work

Polymorphisms in the type A blaZ gene as determinants of the cefazolin inoculum effect in Staphylococcus aureus

Year: 2024

Type: article

Abstract: ABSTRACT Plasmids containing the wild-type (WT) or mutant type A blaZ ( blaZ A ) gene (mutations at codons 226, 229, or both 226 and 229) were constructed and transformed into Staphylococcus aureus RN4220, yielding the strains WT-blaZ, M226-blaZ, M229-blaZ, and MB-blaZ. The high-inoculum cefazolin MIC was significantly lower in MB-blaZ and M226-blaZ than in WT-blaZ but not in M229-blaZ, suggesting that the single nucleotide polymorphism at codon 226 in blaZ A contributes to the cefazolin inoculum effect.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01106-24

Authors: Shinwon Lee, Sohee Park, Jeong Nam Kim, Soon Ok Lee, Jeong Eun Lee, Sun Hee Lee

Institutions: Pusan National University Hospital, Pusan National University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Research Foundation, Ministry of Science, ICT and Future Planning, National Research Foundation of Korea