Work

Enzymatic Peroxidation in the Chemoenzymatic Synthesis of 13-Oxoverruculogen

Year: 2024

Type: article

Abstract: Verruculogens are fumitremorgin alkaloids that contain an eight-membered endoperoxide ring. Due to their unusual structure and bioactivity, there has been much interest in these natural products since their discovery over forty years ago. Similarly, interest in their biosynthesis resulted in the discovery of verruculogen synthase (FtmOx1) that catalyzes endoperoxide formation in these natural products. Herein, we describe our work in this area through the chemoenzymatic synthesis of 13-oxoverruculogen by endoperoxidation of a substrate analog using FtmOx1.

Source: Synlett

DOI: 10.1055/a-2500-7798

Authors: Chi P. Ting, Brandon Singh

Institution: Brandeis University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry