MiR-675 Inhibits Primary Ovarian Tumor Growth and Metastasis by Suppressing EMT and TGFβ Signaling
Year: 2024
Type: article
Abstract: MicroRNAs (miRNAs) can function as either tumor suppressors or oncogenes.This study explores the role of miR-675 in ovarian cancer (OC) using in vitro OC cell lines and an in vivo orthotopic mouse model.We demonstrate that miR-675 expression inhibits primary tumor growth and metastasis by targeting TGFβ1, suppressing epithelial to mesenchymal transition (EMT), and attenuating the TGFβ signaling pathway.Functional assays revealed significant inhibition of cell proliferation, migration, and invasion by miR-675.In addition, miR-675 synergistically enhanced the apoptotic effect of paclitaxel and carboplatin, suggesting potential for combination therapy of miRNA-675 with chemotherapeutic agents.In vivo studies using orthotopic injection of miR-675 expressing and control OC cells in NSG mice demonstrated significant inhibition of primary OC growth and metastasis.These findings indicate that miR-675 is a promising therapeutic target for OC treatment.
Source: Journal of Cancer
DOI: 10.7150/jca.102654
Authors: Xinxin Zhao, Ziping Liu, Yongshuai Li, Shiji Song, Baojin Wang, Lawrence M. Pfeffer, Wenjing Zhang, Junming Yue
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
Funder: National Cancer Institute
Award: G1529221675
OpenAlex ID: W4405256239