Identification of JNK-JUN-NCOA axis as a therapeutic target for macrophage ferroptosis in chronic apical periodontitis
Year: 2024
Type: article
Abstract: The occurrence of ferroptosis in macrophages contributes to the development of CAP. Targeting the JNK/JUN/NCOA4 axis is an effective therapeutic strategy to rescue the periapical lesions from inflammation due to its anti-macrophage ferroptosis function. Consequently, the current study provides support for further investigation on the JNK/JUN/NCOA4 axis as a targeted signaling pathway for CAP treatment.
DOI: 10.7150/ijms.102741
Authors: Yuting Wang, Wenlan Li, Wenli Mu, Abdelrahman Seyam, Yonghui Guan, Yifei Tang, Mingfei Wang, Ying Xin, Xiaomei Guo, Tiezhou Hou, Xiaoyue Guan
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4405256352