Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells
Year: 2024
Type: article
Abstract: Dioscin is a natural plant-derived steroidal saponin that exerts antitumor effects in multiple cancers. It is widely involved in multiple apoptotic pathways and exerts its anti-tumor effects. In this study, we discovered that Dioscin treatment increased the expression of Noxa, thereby inducing the apoptosis of OSCC cells. Previous reports indicate that dysfunction of the BMI1-Noxa axis is frequently observed in multiple cancers. Our study revealed that Dioscin upregulates Noxa by impairing the protein expression of BMI1 in OSCC cells. Dioscin promotes the ubiquitination of BMI1 and facilitates its degradation, leading to upregulation of Noxa expression at the mRNA level and activation of apoptosis. Additionally, Dioscin exhibited potent tumor suppression in xenograft tumor models. In conclusion, our research provides new insights and strategies for inhibiting OSCC cells by investigating the ant-tumor mechanism of the natural compound Dioscin.
Source: Journal of Cancer
DOI: 10.7150/jca.100631
Authors: Jinglin Fang, Ruirui Wang, Xiaoying Li, XiaoCong Wang, Lingling Gong, An Lou, Jie Lu, Xiaoyue Zhang, Qin Zhao, Xinfang Yu, Qiling Zhou, Ming Li
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4405256383